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Sistemas De Control Automatico Benjamin C Kuo Pdf Download


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Sistemas De Control Automatico Benjamin C Kuo Pdf Download


A SCID-Alb/nude mouse model of UT-SCC-14 hSCC was developed. The mice were irradiated with 4, 6 or 8 fractions of 4 Gy each, using fields of 2.0, 3.4 or 5.7 cm diameter, on days 1, 4, 7, 10, 13, 16, 19, 21, 24 and 33, with rest for 2-3 weeks between treatments. The tumour size was measured during the first 10 days after the third treatment. The same dose was then given on days 1, 4, 7, 10, 13, 15, 19, 21, 24 and 26, with rest for 2-3 weeks between treatments. The tumour size was measured on days 5 and 11 after the third treatment.


In conclusion, the results indicate that repopulation continues after fractionated irradiation and that the time-dose relationships for repopulation are complex, both showing a relationship with the dose per fraction, the number of fractions and the dose per fraction per day. The study does not suggest any specific clinical implications of the data obtained.


During 4 weeks in vivo, there were dose-dependent reductions in the uptake of [99 mTc-HMPAO] by tumour tissue. The decrease was 0.19, 0.65 and 0.54 g cm-3 and the recovery half-times were estimated to be 89, 241 and 125 h for 2, 6 and 10 Gy of prostate tumours respectively, and 105, 323 and 359 h for 6, 20 and 40 Gy. The kinetics of recovery were calculated using a mathematical model to describe rebound kinetics, and the physical half-times of decay and recovery were found to be 75 and 305 min, respectively. These results demonstrate a much higher retention time of [99 mTc-HMPAO] in the tumour following irradiation than has been reported in previous in vivo studies, and may be due to differences in the pharmacokinetic behaviour of the radionuclide in vivo and in vitro.


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